Pakistan journal of Advances in Medicine and Medical Research 2022-10-08T19:54:35+00:00 Prof Liaqat Ali Open Journal Systems <p style="user-select: auto;"><strong>AIMS AND SCOPS</strong></p> <p style="user-select: auto;"><strong> (PJAMMR)</strong></p> <p>It is an independent, open-access, worldwide research-based publishing company dedicated to offering a 'peer-reviewed' platform for great researchers and scientists to showcase their results for the advancement of society, in order to stimulate discussion and give an educational forum. We are dedicated to collaborating with the worldwide researcher community to spread open academic research across the globe. We can concentrate on helping our writers while maintaining rigorous publication standards and editorial integrity with the assistance of our academic Editors stationed in universities all around the world. We are dedicated to continuous innovation in order to better fulfill the needs of our communities, as well as to guaranteeing the integrity of the research we publish and advocating for the advantages of accessible research.</p> <p><span data-preserver-spaces="true"> </span><strong><span data-preserver-spaces="true">Our Vision</span></strong></p> <p><span data-preserver-spaces="true">The Vision of Scholar Worldwide is to become one of the simplest platforms for researchers worldwide in providing the advanced multi-disciplinary analysis of the atmosphere that may encourage the best technologies developed towards realizing the goal of the Developed World.</span></p> <p><span data-preserver-spaces="true"> </span><strong><span data-preserver-spaces="true">Our Mission</span></strong></p> <p><span data-preserver-spaces="true">Scholar Worldwide works with an associate to comprehensively cowl the frontier of trends in the scientific field. The mission of Scholar Worldwide Publishers is to contribute to advancing data by promoting quality analysis. Our final goal is to publish a peer-reviewed study in these fields. We attempt with a mission to propagate quality data amongst the readers during this quickly growing analysis world.</span></p> <p><span data-preserver-spaces="true"> </span></p> MRI Diagnostic Accuracy In The Detection Of Emvi, In Carcinoma Rectum Using Histopathology As The Gold Standard 2022-10-06T15:41:07+00:00 Naheed Khan sidrah saeed Irsa Shuaib Mehmood Akhtar Khattak Hina Gul Kalsoom Nawab <p><strong>Background: </strong>Extramural Venous Invasion [EMVI] is the intravenous tumour extension beyond rectal wall in patients with rectal cancer. Being a predictor of worse prognosis, detection of EMVI is important to make decision regarding treatment options</p> <p><strong>Objective: </strong>To determine the diagnostic accuracy of pre-operative MRI in detecting extramural</p> <p>vascular invasion in patients with rectal cancer, taking histopathology as gold standard.</p> <p> </p> <p><strong>Materials &amp; Methods: </strong>Total 118 patients who did MRI in Kuwait Teaching Hospital Peshawar for Rectal carcinoma from Feb 2020 till March 2021 were included in the study. Patients were examined with 0.3 Tesla MRI machine using MRI sequences T2WI, T1WI, FLAIR and DWI. Post op specimens were sent in formalin for histopathological assessment. Data including MRI features and Histopathological findings were assessed with SPSS version 24.</p> <p> </p> <p><strong>Results: </strong>Our study included 118 rectal cancer patients, 55.1% (85) male and 44.9% (70) female. 31-</p> <p>100 in 10-year increases. 31-50 and 41-50 had 4 instances (3.4%). Twenty (16.9%) patients were</p> <p>between 51 and 60, 22 (18.6%) were between 61 and 70, 35 (29.7%) were between 71 and 80, 11</p> <p>(9.3%) were between 81 and 90, and 22 (18.6%) were between 91 and 100. MRI results found 57</p> <p>EMVI-positive and 61 negative individuals. 45 (38.1%) patients had EMVI, whereas 73 (61.9%) did not. Cross-tabulation was utilised to analyse MRI's sensitivity, specificity, PPV, and NPV in diagnosing EMVI. MRI was 83.3% sensitive, 69% specific, 60% positive predictive, and 88.3% negative predictive. EMVI correlates with neoplastic mass.</p> <p> </p> <p><strong>Conclusion: </strong>Diagnostic accuracy, including sensitivity, specificity, positive predictive value, and negative predictive value, is high using MRI to identify EMVI in rectal cancer.</p> <p> </p> <p><strong>Keywords: </strong>Carcinoma Rectum, Extramural Venous Invasion, MRI, Mesorectal Fascia.</p> <p> </p> 2022-10-06T00:00:00+00:00 Copyright (c) 2022 Pakistan journal of Advances in Medicine and Medical Research COVID-19, Developing Countries Inefficient Lockdown Policies Vs Door To Door Vaccination Campaign, What Should Be The Future Move? 2022-08-13T15:59:50+00:00 Anila Basit Ittehad Ul Mulk Abid Ullah Muhmmand Bilal <p>Since the start, COVID-19 has had a wave pattern, fluctuating from surge to nearly touching the base on the graph. Managing a pandemic, that is highly contagious and viral in nature; SOPs and vaccination, were means of coping with such pandemic. But as vaccines had yet to be discovered when COVID-19 started, the only way to stop it was to impose a lockdown nationwide and practice strict SOPs to control virus spread. Since day one, the developing countries are finding it hard to make its subjects compliant with the lockdown protocols as declared by their governments</p> 2022-08-13T00:00:00+00:00 Copyright (c) 2022 Pakistan journal of Advances in Medicine and Medical Research A Tertiary Care Center's Conventional Percutaneous Nephrolithotomy (PCNL) Complications Rate 2022-05-27T20:28:21+00:00 Sami ullah MUHAMMAD ASIF NAVEED HAROON IJAZ ALI AZARA GHANI <p><strong><span dir="ltr" role="presentation">INTRODUCTION:</span></strong><br role="presentation"><span dir="ltr" role="presentation">In A Tertiary Care Hospital, Monitor The Complication Rate Of Conventional Percutaneous Nephrolithotomy (PCNL).</span><br role="presentation"><strong><span dir="ltr" role="presentation">MATERIALS AND METHODS:</span></strong><br role="presentation"><span dir="ltr" role="presentation">From January 2016 To January 2020, This Descriptive Research Was Carried Out In The Department Of Urology</span><br role="presentation"><span dir="ltr" role="presentation">At Lady Reading Hospital In Peshawar, Pakistan. Four Hundred And Forty-Nine Individuals Who Received</span><br role="presentation"><span dir="ltr" role="presentation">Standard PCNL Were Studied. Preoperative Non-Contrast CT KUB Was Performed On All Patients. Once The 6fr</span><br role="presentation"><span dir="ltr" role="presentation">Ureteric Catheter Had Been Inserted Via The Lithotomy Position, The Patient Was Placed Into A Prone Position,</span><br role="presentation"><span dir="ltr" role="presentation">And The Procedure Was Completed Successfully. Prone Posture And 30FR Am Platz Sheaths Were Employed For </span><span dir="ltr" role="presentation">All Surgeries, With Fluoroscopy Guiding Them. The Use Of A Pneumatic Lithoclast Accomplished Stone</span><br role="presentation"><span dir="ltr" role="presentation">Fragmentation. A 16-Fr Foley Catheter Was Used As A Nephrostomy Tube In All Instances. Six Surgeons, Each</span><br role="presentation"><span dir="ltr" role="presentation">With A Minimum Of Four Years Of PCNL Experience, Carried Out These Operations. Perioperative Complications</span><span dir="ltr" role="presentation">Were Rated Using A Modified Clavien Grading Scale</span><span dir="ltr" role="presentation">.</span><br role="presentation"><strong><span dir="ltr" role="presentation">RESULTS:</span></strong><br role="presentation"><span dir="ltr" role="presentation">In All, 46.9 Percent Of The Patients Had Some Issue. There Were 120 (27%) And 54 (12%) Cases With Clavier</span><br role="presentation"><span dir="ltr" role="presentation">Grade I And Grade II Complications, Respectively. Antipyretics Were Used To Treat Transitory Fever In 67 (15%)</span><br role="presentation"><span dir="ltr" role="presentation">Patients Who Experienced Grade I Problems. In Comparison, Simple Pressure Dressings At The Bed Site Addressed </span><span dir="ltr" role="presentation">Nephrostomy Site Leaking In 53(12%) Of The Patients. Among Those Who Suffered From Complications Of Grade </span><span dir="ltr" role="presentation">II, 45 (10 Percent) Needed Blood Transfusions, While 9 (2 Percent) Were Ill With Sepsis And Required Intravenous </span><span dir="ltr" role="presentation">Antibiotics To Treat It. Patients With Grade Iiia Complications, Such As Persistent Bleeding In 4 (0.8%) Patients </span><span dir="ltr" role="presentation">Treated With Percutaneous Angioembolization And 6 (1.2%) Who Needed Perinephric Collection Draining, </span><span dir="ltr" role="presentation">Developed 10 (2%). DJ Stenting Was Performed In 24 (5.3%) Of The Patients Who Had PCS Damage Or Chronic </span><span dir="ltr" role="presentation">Leaking From A Nephrostomy Site, And A Colostomy Was Performed In 1 (0.2%) Of The Patients Who Had The </span><span dir="ltr" role="presentation">Colonic Injury. There Was No Evidence Of A Problem Of Category IV Severity. Excessive Hemorrhaging Was To </span><span dir="ltr" role="presentation">Blame For A Meagre 0.4% Of The Deaths.</span></p> <p><span dir="ltr" role="presentation"><strong>CONLCUSION:</strong><br role="presentation">Nephrolithotomy Using Percutaneous Nephrolithotomy Is A Safe Operation That Is Cost-Effective And Well-<br role="presentation">Tolerated. Minor Problems Like Transient Fever Or Nephrostomy Site Leaking Are Common, Although They<br role="presentation">Usually Go Away Independently. The Level Of Complexity Has Been Reduced To Almost Nothing Thanks To The<br role="presentation">Shrinking Of Pcnls From Conventional To Mini, Ultra Mini, And Micro.<br role="presentation"><strong>KEYWORDS:</strong> Complications, Territorial Care, Conventional, PCNL</span></p> 2022-05-29T00:00:00+00:00 Copyright (c) 2022 Pakistan journal of Advances in Medicine and Medical Research Surgical Intervention for the Treatment of Multiple Glioblastomas 2022-07-22T18:17:39+00:00 Muhammad Shoaib author Sajid Khan . Syed Nasir Shah . Imran Ullah . Bakth Jamal . <p><strong>Background:</strong> Even when Glioblastoma (GB) is monitored, a fast rate of progression is almost inevitable. Early studies highlighted the endurance benefits of removing the GB, but few studies have evaluated the function of surgical intervention in treating Glioblastoma.</p> <p><strong>Objective:</strong> This study aims to evaluate the outcomes of glioblastoma patients' surgical resections.</p> <p><strong>Methods:</strong> the research was carried out at &nbsp;MTI LRH Peshawar Hospital. To find 30 patients with progressing GB, records for everyone who had a glioblastoma biopsy or had it removed between January 2015 and January 2018 were identified and evaluated retrospectively. The median survival and 90% CI were derived by the Kaplan-Meier method. The multivariate analysis was conducted for age, Karnofsky score, amount of resection, tumor size, and tumor multifocality of survival following the advancement of the disease using the Cox Proportional Risks model.</p> <p><strong>Results:</strong>&nbsp;Patients with advanced illnesses underwent the first known resection. Patients who had not yet had resections had median survival after progression of 10.6 months for them and 4.0 months for them. In multivariable analysis, surgical intervention and KPS 0.70 (HR 0.411) were associated with improved survival after GBM progression.</p> <p><strong>Conclusions:</strong> Operative intervention for progressing Glioblastoma is effective in treating the symptoms in the current maximum non-operative treatment, but the survival of the patients is restricted. More research is needed to determine if surgical surgery can lengthen post-progressive endurance in people with progressive GB.</p> 2022-07-22T00:00:00+00:00 Copyright (c) 2022 Pakistan journal of Advances in Medicine and Medical Research Anti-Glomerular Basement Membrane Antibody Disease With Normal Renal Function Was Discovered At The Miangul Abdul Haq Jahanzeb Kidney Hospital In Swat A Case Report Study. 2022-08-02T21:56:56+00:00 Rahmat Ali Khan Syed Munib Mohammad Shahzad . Mufti Baleegh . Liaqat Ali . Mohammad Shahid . <p><strong>Abstracts</strong></p> <p><strong> </strong><strong>Background</strong>: Autoantibodies against the 3-chain of type IV collagen in the GBM induce a rare autoimmune illness known as anti-glomerular basement membrane (GBM) antibody disease, which causes rapidly progressing glomerulonephritis.</p> <p><strong>Objective:</strong> Anti-GBM nephritis was the cause of hematuria and proteinuria in a 7-year-old child who was screened during a urine screening program at school. There were no abnormalities in her blood pressure or serum creatinine levels. Her hematuria and proteinuria lasted for many months, desp ite her best efforts. A percutaneous renal biopsy was conducted because a spot urine protein to creatinine ratio of roughly 7 g/g Cree was observed. For the whole GBM, immunofluorescent labelling revealed a linear pattern. X-rays of the chest came back normal. Immunoassays performed to check for anti-GBM antibodies returned slightly elevated, leading to the diagnosis of anti-GBM illness with normal renal function. An intravenous high-dose methylprednisolone infusion and cyclophosphamide were the primary treatments. The medication was fast successful, with an immediate drop in anti-GBM titers and proteinuria.</p> <p><strong> </strong><strong>Methods :</strong> From January 2021 to July 2021, the study was conducted in the department of nephrology at the Miangul Abdul Haq Jahanzeb Kidney Hospital after ethical clearance for hospital administration of this study.</p> <p><strong>Results :</strong>Anti-GBM illness in infants with intact renal function is very uncommon. For this reason, professionals must carefully pick an appropriate therapy for youngsters since the prognosis is grim.</p> <p><strong>Conclusion :</strong>As shown in Figures 1 to 3 things are true of anti-GBM illness. Anti-GBM illness was suspected even though her kidneys were in good shape. A VUR might have caused this with a bladder issue as a secondary condition source. As an anti-GBM medication, DFPP works well for those with normal renal function.</p> 2022-08-02T00:00:00+00:00 Copyright (c) 2022 Pakistan journal of Advances in Medicine and Medical Research