Exploring the Relationship Between Chronic Obstructive Pulmonary Disease and Serum Lipid Levels

Original Article

Abstract

Background:Chronic obstructive pulmonary disease (COPD) is a major global health problem associated with chronic inflammation, oxidative stress, and metabolic disturbances, including dyslipidemia. Dyslipidemia contributes to increased cardiovascular risk, which is commonly observed in COPD patients. Understanding the relationship between serum lipid levels and COPD severity is essential for comprehensive disease management.

Objective:To investigate the association between serum lipid profile and COPD severity, and to assess the correlation between dyslipidemia and disease progression.

Methods:A total of 100 patients diagnosed with COPD were included. Serum lipid parameters, including total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, were measured. COPD severity was classified using GOLD criteria based on spirometry. Pearson correlation coefficient was applied to assess relationships between lipid levels and disease severity. A p-value < 0.05 was considered statistically significant.

Results:
The study included 100 patients (60 males, 40 females) with a mean age of 62 ± 8 years. Patients with severe COPD had significantly higher total cholesterol and LDL levels. Approximately 60% had low HDL (<40 mg/dL), while 40% had elevated triglycerides (>150 mg/dL). Increased LDL levels were significantly associated with greater COPD severity (p = 0.02), and elevated triglycerides also showed a significant association (p = 0.03).

Conclusion:
Dyslipidemia is significantly associated with COPD severity. Comprehensive management of COPD should include evaluation and control of lipid abnormalities to reduce cardiovascular risk and improve patient outcomes