A Case Report Study at the Miangul Abdul Haq Jahanzeb Kidney Hospital in Swat Found Glomerular Basement Membrane Antibody Disease with Normal Renal Function.

Rahmat Ali Khan, Syed Munib, Mohammad Shahzad, Mufti Baleegh, Liaqat Ali , Mohammad Shahid

Abstract

Background: The common autoimmune condition known as anti-glomerular basement membrane (GBM) antibody disease, which results in quickly advancing glomerulonephritis, is brought on by autoantibodies against the 3-chain of type IV collagen in the GBM.

Objective: Hematuria and proteinuria in a 7-year-old kid who underwent a pee screening programme at school were caused by (anti-GBM) nephritis. Her blood pressure and serum creatine values were both normal. Despite her best attempts, her hematuria and proteinuria continued for many months. A spot urinary protein to creatinine ratio of about 7 g/g Cree was noted, prompting a laparoscopic kidney biopsy. Immunofluorescent staining showed a straight pattern throughout the entire GBM. Chest X-rays revealed nothing abnormal. It was determined that the patient had (anti-GBM) disease with normal kidney function after immunoassays to screen for (anti-GBM) antibodies yielded mildly increased results. The main therapies were a continuous high-dose methylprednisolone injection and chemotherapy. The drug worked quickly, resulting in a rapid decrease in (anti-GBM) titers and proteinuria.

Methods: This Case Report study was conducted in the department of nephrology at the Miangul Abdul Haq Jahanzeb Kidney Hospital From January 2021 to July 2021 after ethical clearance for hospital administration of this study.

Results: (anti-GBM) illness in infants with intact renal function is uncommon. For this reason, professionals must carefully pick an appropriate therapy for youngsters since the prognosis is grim.

Conclusion: Figures 1 to 3 show that things are true of (anti-GBM) illness. (anti-GBM) infection was suspected even though her kidneys were in good shape. A VUR might have caused this with a bladder issue as a secondary condition source. As an (anti-GBM) medication, DFPP works well for those with normal renal function.

Keywords: Anti-GBM, Pediatrics, Normal renal function, School urine screening programmed, case report