Surgical Intervention for the Treatment of Multiple Glioblastomas A Multi-Centre Study.

Muhammad Shoaib, Sajid Khan, Syed Nasir Shah, Imran Ullah, Bakth Jamal

Abstract

Background: This trial tested surgery therapy for numerous glioblastomas. A multi-centre study enlisted 32 multiple GBM cases. The outcomes were overall survival, progression-free survival, time to return, and quality of life. Biopsy, debulking, and excision were performed. Overall survival was 13.5 months, and progression-free survival was 8.5 months. Postoperative quality of life improved considerably. Multiple glioblastomas can be treated safely and effectively with surgery.

Objective: This study aims to evaluate the outcomes of glioblastoma patients' surgical resections.

 Methods: the research was carried out at MTI LRH Peshawar Hospital. To find 30 patients with progressing GB, records for everyone who had a glioblastoma biopsy or had it removed between January 2015 and January 2018 were identified and evaluated retrospectively. The median survival and 90% CI were derived by the Kaplan-Meier method. The multivariate analysis was conducted for age, Karnofsky score, amount of resection, tumour size, and tumour multifocality of survival following the advancement of the disease using the Cox Proportional Risks model.

 Results: Patients with advanced illnesses underwent the first known resection. Patients who had not yet had resections had median survival after progression of 10.6 months for them and 4.0 months for them. In multivariable analysis, surgical intervention and KPS 0.70 (HR 0.411) were associated with improved survival after GBM progression. The median overall survival was 13.5 months, with a 90% CI of 8.2 to 18.8 months. The median progression-free survival was 8.5 months, with a 90% CI of 5.3 to 11.7 months. Quality of life scores improved significantly postoperatively.

 Conclusions: Operative intervention for progressing Glioblastoma effectively treats the symptoms in the current maximum non-operative treatment, but the survival of the patients is restricted. More research is needed to determine if surgical surgery can lengthen post-progressive endurance in people with progressive GB.

 Keywords: Surgical Intervention, Treatment, Multiple Glioblastomas